INSERM U1163, Imagine Institute, Paris Descartes University, Paris, France.
Laurence Legeai-Mallet is currently director of research at Imagine Institute-Paris Descartes University. She received her PhD in genetic from University of Paris V, she is a member of International skeletal dysplasia Society, European Skeletal Dysplasia Network and the French reference center of bone dysplasias. She has been involved in the field of skeletal disease since 1993. Her research field ranges from identification of disease genes involved in cartilage and bone disorders, to the understanding of bone development and skeletal pathologies, to the development of therapeutic approaches. Her research focuses on a family of FGFR3-related osteochondrodysplasias, studying human pathology using clinical data and several relevant cellular and murine models. In 2009, she initiated several collaborations with both an academic chemistry laboratory (Paris Descartes university) and pharmaceutical company to develop therapeutic approaches for osteochondroplasias. In 2012, in collaboration with BioMarin, she reported the therapeutic potential of a novel C-type natriuretic peptide analog (BMN 111-vosoritide) as the first investigational therapy for the most frequent dwarfism, achondroplasia. Currently, she is developing new therapeutic approaches for craniosynostoses and chondrodysplasias. Her laboratory leads to an understanding of cartilage growth plate and bone development in skeletal rare disorders.
